One-pot and sustainable liquid-phase peptide extension for synthesis of C-terminal amidation peptides aided by small molecular tags-Reference-Cited by-同舟云学术

One-pot and sustainable liquid-phase peptide extension for synthesis of C-terminal amidation peptides aided by small molecular tags

Published:2023 Issue:24 Volume:10 Page:6158-6165
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Li Haidi¹^ORCID,Jin Yuankui¹,Wang Lianjun¹,Zhang Linyan¹,Liu Tianyu¹,Liu Yu¹,Liang Taigang¹

Affiliation:

1. Shanxi Provincial Key Laboratory of Drug Synthesis and Novel Pharmaceutical Preparation Technology, School of Pharmacy, Shanxi Medical University, Taiyuan, Shanxi, 030001, P. R. China

Abstract

A series of phosphonate or aliphatic-based tags were developed to achieve sustainable peptide synthesis, resulting in over a 10-fold reduction in solvent usage compared to SPPS.

Funder

Shanxi Provincial Key Research and Development Project

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/QO/D3QO01248D

Reference26 articles.

1. Trends in peptide drug discovery

2. The Current State of Peptide Drug Discovery: Back to the Future?

3. Prebiotic Peptides: Molecular Hubs in the Origin of Life

4. Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide

5. Sustainability Challenges in Peptide Synthesis and Purification: From R&D to Production

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