Discovery of novel diarylpyrimidines as potent HIV-1 NNRTIs by investigating the chemical space of a less explored “hydrophobic channel”-Reference-Cited by-同舟云学术

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Discovery of novel diarylpyrimidines as potent HIV-1 NNRTIs by investigating the chemical space of a less explored “hydrophobic channel”

Published:2018 Issue:6 Volume:16 Page:1014-1028
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zhou Zhongxia¹²³⁴⁵^ORCID,Liu Tao¹²³⁴⁵,Kang Dongwei¹²³⁴⁵^ORCID,Huo Zhipeng¹²³⁴⁵,Wu Gaochan¹²³⁴⁵^ORCID,Daelemans Dirk⁶⁷⁸⁹,De Clercq Erik⁶⁷⁸⁹,Pannecouque Christophe⁶⁷⁸⁹,Zhan Peng¹²³⁴⁵,Liu Xinyong¹²³⁴⁵

Affiliation:

1. Department of Medicinal Chemistry

2. Key Laboratory of Chemical Biology (Ministry of Education)

3. School of Pharmaceutical Sciences

4. Shandong University

5. 250012 Jinan

6. Rega Institute for Medical Research

7. K.U.Leuven

8. B-3000 Leuven

9. Belgium

Abstract

We described the identification of novel HIV-1 NNRTIs via exploration of the chemical space of a seldom explored “hydrophobic channel”.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C7OB02828H

Reference45 articles.

1. The HIV-1 Reverse Transcription (RT) Process as Target for RT Inhibitors

2. Non-Nucleoside HIV-1 Reverse Transcriptase (RT) Inhibitors: Past, Present, and Future Perspectives

3. U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication

4. Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants

5. TMC278, a Next-Generation Nonnucleoside Reverse Transcriptase Inhibitor (NNRTI), Active against Wild-Type and NNRTI-Resistant HIV-1

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1. Deciphering the enigmas of non‐nucleoside reverse transcriptase inhibitors (NNRTIs): A medicinal chemistry expedition towards combating HIV drug resistance;Medicinal Research Reviews;2024-08-26

2. Design and synthesis of Fsp³‐enriched spirocyclic‐substituted diarylpyrimidine derivatives as novel HIV‐1 NNRTIs;Chemical Biology & Drug Design;2024-03

3. Strategies in the Design and Development of Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs);Viruses;2023-09-25

4. Design of novel DABO derivatives as HIV-1 RT inhibitors using molecular docking, molecular dynamics simulations and ADMET properties;Journal of Biomolecular Structure and Dynamics;2023-06-05

5. N-Phenyl-1-(phenylsulfonyl)-1H-1,2,4-triazol-3-amine as a New Class of HIV-1 Non-nucleoside Reverse Transcriptase Inhibitor;Journal of Medicinal Chemistry;2023-05-02

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