Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants-Reference-Cited by-同舟云学术

Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants

Published:2004-04-06 Issue:10 Volume:47 Page:2550-2560
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Das Kalyan¹,Clark, Arthur D.¹,Lewi Paul J.¹,Heeres Jan¹,de Jonge Marc R.¹,Koymans Lucien M. H.¹,Vinkers H. Maarten¹,Daeyaert Frederik¹,Ludovici Donald W.¹,Kukla Michael J.¹,De Corte Bart¹,Kavash Robert W.¹,Ho Chih Y.¹,Ye Hong¹,Lichtenstein Mark. A.¹,Andries Koen¹,Pauwels Rudi¹,de Béthune Marie-Pierre¹,Boyer Paul L.¹,Clark Patrick¹,Hughes Stephen H.¹,Janssen Paul A. J.¹,Arnold Eddy¹

Affiliation:

1. Center for Advanced Biotechnology and Medicine and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, Center for Molecular Design, Janssen Pharmaceutica NV, Vosselaar, Belgium, Janssen Research Foundation, Spring House, Pennsylvania, Tibotec, 2800 Mechelen, Belgium, and HIV Drug Resistance Program, NIH National Cancer InstituteFrederick, Frederick, Maryland 21702

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm030558s

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4. Potent and highly selective human immunodeficiency virus type 1 (HIV-1) inhibition by a series of alpha-anilinophenylacetamide derivatives targeted at HIV-1 reverse transcriptase.

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