A protease inhibition strategy based on acceleration of autolysis-Reference-Cited by-同舟云学术

A protease inhibition strategy based on acceleration of autolysis

Published:2015 Issue:27 Volume:51 Page:5959-5962
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Lv Yan¹²³⁴⁵,Zhang Jianbin¹²³⁴⁵,Wu Hao¹²³⁴⁵,Zhao Shan¹²³⁴⁵,Song Yizhe¹²³⁴⁵,Wang Shujun¹²³⁴⁵,Wang Bing¹²³⁴⁵,Lv Guojun¹²³⁴⁵,Ma Xiaojun¹²³⁴⁵

Affiliation:

1. Laboratory of Biomedical Materials Engineering

2. Dalian Institute of Chemical Physics

3. Chinese Academy of Sciences

4. Dalian 116023

5. P. R. China

Abstract

An iconoclastic protease inhibition strategy based on autolysis acceleration: proteases are concentrated and induced to self-digest by a polymer via electrostatic interaction. Such a catalytic cycle results in high inhibition efficiency.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2015/CC/C5CC01448D

Reference23 articles.

1. Chemopreventive Agents Protease Inhibitors

2. Polyoxometalate HIV-1 Protease Inhibitors. A New Mode of Protease Inhibition

3. Protease inhibitors as potential disease-modifying therapeutics for Alzheimer’s disease

4. Protease Inhibitors: Current Status and Future Prospects

5. Design of Potent Aspartic Protease Inhibitors to Treat Various Diseases

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