Excited-state intramolecular proton transfer in a bioactive flavonoid provides fluorescence observables for recognizing its engagement with target proteins

Author:

Vanossi Davide1234ORCID,Caselli Monica1234ORCID,Pavesi Giorgia5234,Borsari Chiara5234ORCID,Linciano Pasquale5234,Costi Maria Paola5234,Ponterini Glauco5234ORCID

Affiliation:

1. Department of Chemical and Geological Sciences

2. University of Modena and Reggio Emilia (UNIMORE)

3. 41125 Modena

4. Italy

5. Department of Life Sciences

Abstract

Intra- vs. intermolecular hydrogen-bond formation and ESIPT in a bioactive flavonoid result in different emission properties and provide a clue for recognizing its binding to target proteins.

Funder

Seventh Framework Programme

Publisher

Springer Science and Business Media LLC

Subject

Physical and Theoretical Chemistry

Reference31 articles.

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2. C. F. Chignell , Fluorescence spectroscopy as a tool for studying drug interactions with biological systems , in Fluorescence techniques in cell biology , ed. A. A. Thaer and M. Sernetz , Springer , Berlin, Heidelberg , 1973 , pp. 345–357

3. Fluorescent Indicators for Intracellular pH

4. Solvent and Environmental Effects , in Principles of fluorescence spectroscopy , ed. J. R. Lakowicz , Springer , Boston , 3rd edn, 2006 , ch. 6

5. Drastic changes in the fluorescence properties of NBD probes with the polarity of the medium: involvement of a TICT state?

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