High-Throughput Phenotypic Screening and Machine Learning Methods Enabled the Selection of Broad-Spectrum Low-Toxicity Antitrypanosomatidic Agents-Reference-Cited by-同舟云学术

High-Throughput Phenotypic Screening and Machine Learning Methods Enabled the Selection of Broad-Spectrum Low-Toxicity Antitrypanosomatidic Agents

Published:2023-11-03 Issue:22 Volume:66 Page:15230-15255
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Linciano Pasquale¹^ORCID,Quotadamo Antonio¹,Luciani Rosaria¹,Santucci Matteo¹,Zorn Kimberley M.²,Foil Daniel H.²,Lane Thomas R.²^ORCID,Cordeiro da Silva Anabela³⁴,Santarem Nuno³⁴,B Moraes Carolina⁵,Freitas-Junior Lucio⁵,Wittig Ulrike⁶,Mueller Wolfgang⁶,Tonelli Michele⁷^ORCID,Ferrari Stefania¹^ORCID,Venturelli Alberto¹⁸,Gul Sheraz⁹¹⁰^ORCID,Kuzikov Maria⁹¹⁰^ORCID,Ellinger Bernhard⁹¹⁰,Reinshagen Jeanette⁹¹⁰,Ekins Sean²^ORCID,Costi Maria Paola¹^ORCID

Affiliation:

1. Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy

2. Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States

3. Institute for Molecular and Cell Biology, 4150-180 Porto, Portugal

4. Instituto de Investigaçao e Inovaçao em Saúde, Universidade do Porto and Institute for Molecular and Cell Biology, 4150-180 Porto, Portugal

5. Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), 13083-970 Campinas, São Paulo, Brazil

6. Scientific Databases and Visualization Group and Molecular and Cellular Modelling Group, Heidelberg Institute for Theoretical Studies (HITS), D-69118 Heidelberg, Germany

7. Department of Pharmacy, University of Genoa, Viale Benedetto XV n.3, 16132 Genoa, Italy

8. TYDOCK PHARMA S.r.l., Strada Gherbella 294/b, 41126 Modena, Italy

9. Fraunhofer Translational Medicine and Pharmacology, Schnackenburgallee 114, D-22525 Hamburg, Germany

10. Fraunhofer Cluster of Excellence Immune-Mediated Diseases CIMD, Schnackenburgallee 114, D-22525 Hamburg, Germany

Funder

National Institute of Environmental Health Sciences

FP7 Health

Universit? Degli Studi di Modena e Reggio Emila

European Cooperation in Science and Technology

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01322

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4. Vector-Borne Diseases, 2020. https://www.who.int/news-room/fact-sheets/detail/vector-borne-diseases (accessed June 11, 2023).

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