Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti-<i>Trypanosoma brucei</i> Agents-Reference-Cited by-同舟云学术

Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti-Trypanosoma brucei Agents

Published:2024-07-02 Issue:8 Volume:10 Page:2755-2774
ISSN:2373-8227
Container-title:ACS Infectious Diseases
language:en
Short-container-title:ACS Infect. Dis.

Author:

Francesconi Valeria¹,Rizzo Marco¹,Pozzi Cecilia²³^ORCID,Tagliazucchi Lorenzo⁴⁵^ORCID,Konchie Simo Claude U.⁴,Saporito Giulia⁴,Landi Giacomo²,Mangani Stefano²^ORCID,Carbone Anna¹^ORCID,Schenone Silvia¹,Santarém Nuno⁶,Tavares Joana⁶,Cordeiro-da-Silva Anabela⁶⁷^ORCID,Costi Maria Paola⁴^ORCID,Tonelli Michele¹^ORCID

Affiliation:

1. Department of Pharmacy, University of Genoa, viale Benedetto XV n.3, Genoa 16132, Italy

2. Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via Aldo Moro 2, Siena 53100, Italy

3. Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine (CIMMP), Via Luigi Sacconi 6, Sesto Fiorentino (FI) 50019, Italy

4. Department of Life Science, University of Modena and Reggio Emilia, via Campi 103, Modena 41125, Italy

5. Doctorate School in Clinical and Experimental Medicine (CEM), University of Modena and Reggio Emilia, Via Campi 287, Modena 41125, Italy

6. i3S - Institute for Research and Innovation in Health, University of Porto, Rua Alfredo Allen, 208, Porto 4200-135, Portugal

7. Department of Life Science, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, Porto 4050-313, Portugal

Funder

European Social Fund Plus

Funda??o para a Ci?ncia e a Tecnologia

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.4c00113

Reference62 articles.

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2. Parasitic Infection and Immunity—A Special Biomedicines Issue

3. Human African trypanosomiasis

4. Trypanosomiasis, human African (sleeping sickness). https://www.who.int/news-room/fact-sheets/detail/trypanosomiasis-human-african-(sleeping-sickness) (accessed May 2023).

5. Recent progress in diagnosis and treatment of Human African Trypanosomiasis has made the elimination of this disease a realistic target by 2030