Hydroxylation of anilides by engineered cytochrome P450BM3
Author:
Affiliation:
1. Department of Chemistry
2. University of Oxford
3. Chemistry Research laboratory
4. Oxford
5. UK
6. Inorganic Chemistry Laboratory
7. Syngenta UK
8. Jealott's Hill International Research Centre
9. Bracknell
Abstract
Cytochrome P450BM3mutants achieve selectivepara-hydroxylation of substitutedN-sulfonylanilines under mild conditions.
Funder
Engineering and Physical Sciences Research Council
Biotechnology and Biological Sciences Research Council
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB02236K
Reference64 articles.
1. The Chemistry of Anilines, ed. Z. Rappoport, John Wiley & Sons, Ltd, Chichester, 2007
2. Nitro Compounds, Aromatic. Ullmann's Encyclopedia of Industrial Compounds, G. Booth, 2000
3. Ruthenium chloride, a new and efficient catalyst for direct amination of arenes with azodicarboxylates
4. Electrophilic Amination of 4-Fluorophenol with Diazenes: A Complete Removal of the Fluorine Atom
5. ZrCl4-promoted halogen migration during an electrophilic amination of halogenated phenolsElectronic supplementary information (ESI) available: spectroscopic data (1H NMR,13C NMR, IR, MS), mp and elemental analysis (or HRMS) for the products 3 and 4. See http://www.rsc.org/suppdata/cc/b2/b203622c/Dedicated to Professor Waldemar Adam, University of Würzburg, Germany, on the occasion of his 65th birthday.
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