A natural product inspired fragment-based approach towards the development of novel anti-bacterial agents-Reference-Cited by-同舟云学术

A natural product inspired fragment-based approach towards the development of novel anti-bacterial agents

Published:2016 Issue:7 Volume:7 Page:1387-1391
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Austin Michael J.¹²³⁴,Hearnshaw Stephen J.⁵⁶⁷⁴,Mitchenall Lesley A.⁵⁶⁷⁴,McDermott Paul J.¹²³⁴,Howell Lesley A.¹²³⁴,Maxwell Anthony⁵⁶⁷⁴,Searcey Mark¹²³⁴

Affiliation:

1. School of Pharmacy

2. University of East Anglia

3. Norwich NR4 7TJ

4. UK

5. Department of Biological Chemistry

6. John Innes Centre

7. Norwich NR4 7UH

Abstract

Simocyclinone D8 served as a natural product inspiration for the synthesis of a new DNA gyrase inhibitor.

Funder

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/MD/C6MD00229C

Reference31 articles.

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3. Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design

4. The isolation, total synthesis and structure elucidation of chlorofusin, a natural product inhibitor of the p53–MDM2 protein–protein interaction

5. Identification of a new p53/MDM2 inhibitor motif inspired by studies of chlorofusin

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