Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design
Author:
Affiliation:
1. Cubist Pharmaceuticals, Inc., 65 Hayden Avenue, Lexington, Massachusetts 02421, United States
2. Evotec U.K., Ltd., 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, United Kingdom
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.5b00368
Reference16 articles.
1. Bacterial DNA replication enzymes as targets for antibacterial drug discovery
2. DNA Topoisomerases: Structure, Function, and Mechanism
3. Structure and mechanism of DNA topoisomerase II
4. New Antibacterial Agents Derived from the DNA Gyrase Inhibitor Cyclothialidine
5. Dual Targeting of GyrB and ParE by a Novel Aminobenzimidazole Class of Antibacterial Compounds
Cited by 39 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Synergistic Synthesis and Computational Analysis of Novel Indazole-2-Pyrone Hybrids: Toxicity, Hirshfeld Surface Insights, and Antiviral Potential against HIV-1 and Coronaviruses;Journal of Molecular Structure;2024-09
2. Bioisosteric replacement strategy leads to novel DNA gyrase B inhibitors with improved potencies and properties;Bioorganic Chemistry;2024-06
3. Modular Approach to Highly Substituted 3-Methylpyridones;The Journal of Organic Chemistry;2024-05-03
4. Investigation of bacterial DNA gyrase Inhibitor classification models and structural requirements utilizing multiple machine learning methods;Molecular Diversity;2024-02-19
5. New N-phenylpyrrolamide inhibitors of DNA gyrase with improved antibacterial activity;RSC Advances;2024
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3