Identification of a new p53/MDM2 inhibitor motif inspired by studies of chlorofusin-Reference-Cited by-同舟云学术

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Identification of a new p53/MDM2 inhibitor motif inspired by studies of chlorofusin

Published:2015-11 Issue:21 Volume:25 Page:4878-4880
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Cominetti Marco M.D.,Goffin Sarah A.,Raffel Ewan,Turner Kerrie D.,Ramoutar Jordann C.,O’Connell Maria A.,Howell Lesley A.,Searcey Mark

Funder

UEA

SAG

EPSRC Mass Spectrometry Service, Swansea

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference17 articles.

1. Isolation and Structure Elucidation of Chlorofusin, a Novel p53-MDM2 Antagonist from a Fusarium sp.

2. The isolation, total synthesis and structure elucidation of chlorofusin, a natural product inhibitor of the p53–MDM2 protein–protein interaction

3. Solid-Phase Synthesis of the Cyclic Peptide Portion of Chlorofusin, an Inhibitor of p53-MDM2 Interactions

4. Synthesis of the Chlorofusin Cyclic Peptide: Assignment of the Asparagine Stereochemistry

5. Synthetic Studies on Chlorofusin: Synthesis of the Cyclic Peptide Portion

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1. Recent Advancements in the Discovery of MDM2/MDM2-p53 Interaction Inhibitors for the Treatment of Cancer;Current Medicinal Chemistry;2023-10

2. Synthesis, Docking Study, and Biological Evaluation of 2‐Phenylchroman‐4‐one Derivatives as Murine Double Minute 2 (MDM2) Inhibitors;ChemistrySelect;2023-01-17

3. Fungal Secondary Metabolites as Inhibitors of the Ubiquitin–Proteasome System;International Journal of Molecular Sciences;2021-12-10

4. Modulating Protein–Protein Interactions by Cyclic and Macrocyclic Peptides. Prominent Strategies and Examples;Molecules;2021-01-16

5. Recent Advances in Peptide-Based Approaches for Cancer Treatment;Current Medicinal Chemistry;2020-03-26

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