Luminescent ruthenium polypyridyl complexes with extended ‘dppz’ like ligands as DNA targeting binders and cellular agents
Author:
Affiliation:
1. School of Chemistry and Trinity Biomedical Sciences Institute (TBSI)
2. Trinity College Dublin
3. The University of Dublin
4. Dublin 2
5. Ireland
6. School of Biochemistry and Immunology and Trinity Biomedical Sciences Institute (TBSI)
Abstract
DNA-binding and phototoxicity of Ru(ii) complexes with ligands derived from pyrazinodipyridophenazine and either phen or TAP as ancillary ligands are reported.
Funder
Irish Research Council
Science Foundation Ireland
Publisher
Royal Society of Chemistry (RSC)
Subject
Inorganic Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/DT/C6DT03792E
Reference87 articles.
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3. Delivering the cell-impermeable DNA ‘light-switching’ Ru(ii) complexes preferentially into live-cell nucleus via an unprecedented ion-pairing method
4. Dual mode of cell death upon the photo-irradiation of a RuIIpolypyridyl complex in interphase or mitosis
5. Pushing the limit: synthesis, photophysical and DNA binding studies of a NIR-emitting Ru(ii)-polypyridyl probe with ‘light switch’ behaviour
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