Catalyst-free ambient temperature synthesis of isoquinoline-fused benzimidazoles from 2-alkynylbenzaldehydes via alkyne hydroamination-Reference-Cited by-同舟云学术

Catalyst-free ambient temperature synthesis of isoquinoline-fused benzimidazoles from 2-alkynylbenzaldehydes via alkyne hydroamination

Published:2019 Issue:1 Volume:21 Page:99-108
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Mishra Manisha¹²³⁴,Twardy Dylan¹⁵⁶⁴,Ellstrom Clifford¹²³⁴,Wheeler Kraig A.¹⁷⁸⁴^ORCID,Dembinski Roman¹⁵⁶⁴⁹,Török Béla¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. University of Massachusetts Boston

3. Boston

4. USA

5. Oakland University

6. Rochester

7. Whitworth University

8. Spokane

9. Centre of Molecular and Macromolecular Studies

Abstract

An efficient environmentally benign route for the synthesis of benzimidazo[2,1-a]isoquinoline has been developed by reacting 2-ethynylbenzaldehyde and related substituted alkynylbenzaldehydes with variously substituted ortho-phenylenediamines and aliphatic amines in ethanol.

Funder

University of Massachusetts Boston

American Chemical Society Petroleum Research Fund

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/GC/C8GC02520G

Reference57 articles.

1. Chemistry and Biology of the Tetrahydroisoquinoline Antitumor Antibiotics