Optimization of the Indenone Ring of Indenoisoquinoline Topoisomerase I Inhibitors-Reference-Cited by-同舟云学术

Optimization of the Indenone Ring of Indenoisoquinoline Topoisomerase I Inhibitors

Published:2007-08-04 Issue:18 Volume:50 Page:4388-4404
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Morrell Andrew¹,Placzek Michael¹,Parmley Seth¹,Grella Brian¹,Antony Smitha¹,Pommier Yves¹,Cushman Mark¹

Affiliation:

1. Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, and the Purdue Cancer Center, Purdue University, West Lafayette, Indiana 47907, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-4255

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm070307%2B

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1. Bifunctional Reagents. Cross-Linking of Pancreatic Ribonuclease with a Diimido Ester1

2. Accumulation of drugs by guinea pig isolated atria. Quantitative correlations

3. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

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