Synthesis of Indenones via Persulfate Promoted Radical Alkylation/Cyclization of Biaryl Ynones with 1,4-Dihydropyridines-Reference-Cited by-同舟云学术

Synthesis of Indenones via Persulfate Promoted Radical Alkylation/Cyclization of Biaryl Ynones with 1,4-Dihydropyridines

Published:2024-01-17 Issue:2 Volume:29 Page:458
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Wang Wanwan¹^ORCID,Yu Lei¹

Affiliation:

1. Jiangsu Key Laboratory of Chiral Pharmaceuticals Biosynthesis, Taizhou University, Taizhou 225300, China

Abstract

The oxidative radical cascade cyclization of alkynes has emerged as a versatile strategy for the efficient construction of diverse structural units and complex molecules in organic chemistry. This work reports an alkyl radical initiated 5-exo-trig cyclization of biaryl ynones with 1,4-dihydropyridines to selectively synthesize indenones.

Funder

National Natural Science Foundation of China

Science and Technology Support Program (Agriculture) of Taizhou

Publisher

MDPI AG

Link

https://www.mdpi.com/1420-3049/29/2/458/pdf

Reference46 articles.

1. Synthesis and structure–activity relationship of novel indene N-oxide derivatives as potent peroxisome proliferator activated receptor γ (PPARγ) agonists;Ahn;Bioorg. Med. Chem. Lett.,2007

2. A new, fast and efficient synthesis of 3-aryl indenones: Intramolecular cyclization of 1, 3-diarylpropynones in superacids;Vasilyev;Tetrahedron Lett.,2004

3. Optimization of the indenone ring of indenoisoquinoline topoisomerase I inhibitors;Morrell;J. Med. Chem.,2007

4. Recent applications of radical cascade reaction in the synthesis of functionalized 1-indenones;Zhang;Chin. Chem. Lett.,2019

5. Carbocycle synthesis via carbopalladation of nitriles;Larock;J. Am. Chem. Soc.,1999

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Liquid–Liquid and Liquid–Solid Interfacial Nanoarchitectonics;Molecules;2024-07-03