Affiliation:
1. Department of Applied Chemistry Kyungpook National University 80 Daehakro Bukgu Daegu 41566 Republic of Korea
2. Department of Environmental Engineering Kyungpook National University 80 Daehakro Bukgu Daegu 41566 Republic of Korea
Abstract
AbstractIn this study, a synthetic method to access benzo[4,5]imidazo[2,1‐a]isoquinolines is developed by the reaction of 2‐(2‐bromoaryl)benzimidazoles with 1,3‐diketones under basic conditions. A reaction pathway involving the initial formation of a C−C coupled intermediate by nucleophilic aromatic substitution and subsequent deacylative cyclocondensation is proposed for this process.
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