Ovomucin and its hydrolysates differentially influenced colitis severity in <i>Citrobacter rodentium</i>-infected mice-Reference-Cited by-同舟云学术

Ovomucin and its hydrolysates differentially influenced colitis severity in Citrobacter rodentium-infected mice

Published:2024 Issue:16 Volume:15 Page:8496-8509
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Bao Xiaoyu¹^ORCID,Ju Tingting¹²,Tollenaar Stephanie¹^ORCID,Sergi Consolato³^ORCID,Willing Benjamin P.¹,Wu Jianping¹^ORCID

Affiliation:

1. Department of Agricultural, Food and Nutritional Science, Faculty of Agricultural, Life and Environmental Sciences, University of Alberta, Edmonton, Alberta, Canada

2. Department of Animal Sciences, Purdue University, West Lafayette, IN, USA

3. Division of Anatomic Pathology, Children's Hospital of Eastern Ontario (CHEO), Ottawa, Ontario, Canada

Abstract

Ovomucin (OVM) and ovomucin-Protex 26L hydrolysate (OP) alleviated Citrobacter rodentium-induced colitis in mice through different protective mechanisms, whereas its pepsin–pancreatin hydrolysate (OPP) exacerbated colitis severity.

Funder

China Scholarship Council

Natural Sciences and Engineering Research Council of Canada

Canada Research Chairs

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/FO/D4FO01813C

Reference68 articles.

1. Citrobacter rodentium: infection, inflammation and the microbiota

2. MyD88 signalling plays a critical role in host defence by controlling pathogen burden and promoting epithelial cell homeostasis during Citrobacter rodentium-induced colitis

3. Toll-like receptor 2 plays a critical role in maintaining mucosal integrity during Citrobacter rodentium-induced colitis

4. Toll-Like Receptor 4 Contributes to Colitis Development but Not to Host Defense during Citrobacter rodentium Infection in Mice

5. Egg Protein Transferrin-Derived Peptides IRW and IQW Regulate Citrobacter rodentium-Induced, Inflammation-Related Microbial and Metabolomic Profiles