Oxidative activation of leinamycin E1 triggers alkylation of guanine residues in double-stranded DNA-Reference-Cited by-同舟云学术

Oxidative activation of leinamycin E1 triggers alkylation of guanine residues in double-stranded DNA

Published:2018 Issue:3 Volume:54 Page:256-259
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Imani Nejad Maryam¹²³⁴,Yang Dong¹⁵⁶⁴⁷^ORCID,Shen Ben¹⁵⁶⁴⁷^ORCID,Gates Kent S.¹²³⁴⁸^ORCID

Affiliation:

1. Department of Chemistry

2. University of Missouri

3. Columbia

4. USA

5. The Scripps Research Institute

6. Jupiter

7. Natural Products Library Initiative at The Scripps Research Institute

8. Department of Biochemistry

Abstract

It may be useful to develop prodrugs that are selectively activated by oxidative stress in cancer cells to release cell-killing reactive intermediates.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CC/C7CC08482J

Reference45 articles.

1. Prodrug strategy for cancer cell-specific targeting: A recent overview

2. Hypoxia-activated prodrugs: paths forward in the era of personalised medicine

3. Design of anticancer prodrugs for reductive activation

4. Targeting hypoxia in cancer therapy

5. Oxidative Stress Is Inherent in Prostate Cancer Cells and Is Required for Aggressive Phenotype

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