Design and synthesis of novel quinazolinone–chalcone hybrids as potential apoptotic candidates targeting caspase-3 and PARP-1: <i>in vitro</i>, molecular docking, and SAR studies-Reference-Cited by-同舟云学术

Design and synthesis of novel quinazolinone–chalcone hybrids as potential apoptotic candidates targeting caspase-3 and PARP-1: in vitro, molecular docking, and SAR studies

Published:2022 Issue:46 Volume:46 Page:22013-22029
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Madbouly Eman A.¹,Lashine El-Sayed M.¹,Al-Karmalawy Ahmed A.²^ORCID,Sebaiy Mahmoud M.¹,Pratsinis Harris³,Kletsas Dimitris³,Metwally Kamel¹⁴

Affiliation:

1. Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

2. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Giza 12566, Egypt

3. Laboratory of Cell Proliferation and Ageing, Institute of Biosciences and Applications, National Centre of Scientific Research “Demokritos”, Athens, Greece

4. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tabuk, Tabuk, Kingdom of Saudi Arabia

Abstract

Novel quinazolinone–chalcone hybrids as potential apoptotic candidates targeting caspase-3 and PARP-1.

Funder

European Regional Development Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NJ/D2NJ04053K

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