Synthesis of bicyclic 2-pyridones by regioselective annulations of heterocyclic ketene aminals with anhydrides-Reference-Cited by-同舟云学术

Synthesis of bicyclic 2-pyridones by regioselective annulations of heterocyclic ketene aminals with anhydrides

Published:2016 Issue:105 Volume:6 Page:103057-103064
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Liu Jin¹²³⁴⁵,Yan Sheng-Jiao¹²³⁴⁵,Cao Zheng-Mao¹²³⁴⁵,Cui Shi-Sheng¹²³⁴⁵,Lin Jun¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University)

2. Ministry Education

3. School of Chemical Science and Technology

4. Yunnan University

5. Kunming

Abstract

An efficient strategy for the synthesis of substituted bicyclic 2-pyridones is developed. The proposed approach is based on the regioselective N-acylation of heterocyclic ketene aminals (HKAs) with methacrylic anhydride or crotonic anhydride.

Funder

National Natural Science Foundation of China

Yunnan Provincial Education Department

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA23451H

Reference60 articles.

1. Structure Guided Lead Generation for M. tuberculosis Thymidylate Kinase (Mtb TMK): Discovery of 3-Cyanopyridone and 1,6-Naphthyridin-2-one as Potent Inhibitors

2. Discovery of Highly Potent, Selective, and Efficacious Small Molecule Inhibitors of ERK1/2

3. Structure activity relationships of 4-hydroxy-2-pyridones: A novel class of antituberculosis agents

4. Therapy of small cell lung cancer with emphasis on oral topotecan

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