Structure Guided Lead Generation for M. tuberculosis Thymidylate Kinase (Mtb TMK): Discovery of 3-Cyanopyridone and 1,6-Naphthyridin-2-one as Potent Inhibitors-Reference-Cited by-同舟云学术

Structure Guided Lead Generation for M. tuberculosis Thymidylate Kinase (Mtb TMK): Discovery of 3-Cyanopyridone and 1,6-Naphthyridin-2-one as Potent Inhibitors

Published:2014-12-23 Issue:2 Volume:58 Page:753-766
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Naik Maruti,Raichurkar Anandkumar,Bandodkar Balachandra S.,Varun Begur V.,Bhat Shantika,Kalkhambkar Rajesh,Murugan Kannan,Menon Rani,Bhat Jyothi,Paul Beena,Iyer Harini,Hussein Syeed¹,Tucker Julie A.¹,Vogtherr Martin¹,Embrey Kevin J.¹,McMiken Helen¹,Prasad Swati²,Gill Adrian¹,Ugarkar Bheemarao G.,Venkatraman Janani,Read Jon¹,Panda Manoranjan

Affiliation:

1. Discovery Sciences, Innovative Medicines, AstraZeneca, Alderley Park, Mereside, Cheshire, SK10 4TG, United Kingdom

2. Department of Bioscience, Innovative Medicines Infection, AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm5012947

Reference33 articles.

1. Advances in the development of new tuberculosis drugs and treatment regimens

2. Tuberculosis drug discovery in the post‐post‐genomic era

3. Lessons from Seven Decades of Antituberculosis Drug Discovery

4. Genes required for mycobacterial growth defined by high density mutagenesis

5. Genetic requirements for mycobacterial survival during infection

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