Discovery of Highly Potent, Selective, and Efficacious Small Molecule Inhibitors of ERK1/2-Reference-Cited by-同舟云学术

Discovery of Highly Potent, Selective, and Efficacious Small Molecule Inhibitors of ERK1/2

Published:2015-02-11 Issue:4 Volume:58 Page:1976-1991
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ren Li¹,Grina Jonas¹,Moreno David¹,Blake James F.¹,Gaudino John J.¹,Garrey Rustam¹,Metcalf Andrew T.¹,Burkard Michael¹,Martinson Matthew¹,Rasor Kevin¹,Chen Huifen²,Dean Brian²,Gould Stephen E.²,Pacheco Patricia²,Shahidi-Latham Sheerin²,Yin Jianping²,West Kristina²,Wang Weiru²,Moffat John G.²,Schwarz Jacob B.²

Affiliation:

1. Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, United States

2. Genentech Inc., 1 DNA Way, South San Francisco, California 94080-4990, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm501921k

Reference21 articles.

1. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

2. Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors

3. MAP kinase signalling pathways in cancer

4. ERK Pathway Inhibitors: How Low Should We Go?

5. Small-Molecule Inhibitors of the ERK Signaling Pathway: Towards Novel Anticancer Therapeutics

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