Manipulating Activity and Chemoselectivity of a Benzaldehyde Lyase for Efficient Synthesis of α-Hydroxymethyl Ketones and One-Pot Enantio-Complementary Conversion to 1,2-Diols

Author:

Zhang Yifan123,Li Yu2,Chen Yangyang2,Liu Weidong2ORCID,Zhao Qing1,Feng Jinhui2ORCID,Yao Peiyuan2ORCID,Wu Qiaqing2ORCID,Zhu Dunming2ORCID

Affiliation:

1. School of Biotechnology, Key Lab of Industrial Fermentation Microbiology of the Ministry of Education, State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin 300457, China

2. National Engineering Research Center of Industrial Enzymes, National Center of Technology Innovation for Synthetic Biology, Key Laboratory of Engineering Biology for Low-Carbon Manufacturing and Tianjin Engineering Research Center of Biocatalytic Technology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 Xi Qi Dao, Tianjin Airport Economic Area, Tianjin 300308, China

3. Haihe Laboratory of Synthetic Biology, 21 West 15th Avenue, Tianjin Airport Economic Area, Tianjin 300308, China

Funder

National Key Research and Development Program of China

Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project

Innovation fund of Haihe Laboratory of Synthetic Biology

Publisher

American Chemical Society (ACS)

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