Human plasma stability during handling and storage: impact on NMR metabolomics

Author:

Pinto Joana1234,Domingues M. Rosário M.5264,Galhano Eulália789,Pita Cristina789,Almeida Maria do Céu789,Carreira Isabel M.1011121314,Gil Ana M.1234

Affiliation:

1. CICECO – Department of Chemistry

2. Campus Universitário de Santiago

3. Universidade de Aveiro

4. 3810-193 Aveiro, Portugal

5. QOPNA – Department of Chemistry

6. University of Aveiro

7. Maternidade Bissaya Barreto

8. Centro Hospitalar e Universitário de Coimbra – CHUC

9. 3000 Coimbra, Portugal

10. Cytogenetics and Genomics Laboratory

11. Faculty of Medicine

12. University of Coimbra

13. Portugal

14. CIMAGO Center for Research in Environment, Genetics and Oncobiology

Abstract

The stability of human plasma composition was investigated by NMR, considering different collection tubes, time at room temperature (RT), short- and long-term storage conditions and up to 5 consecutive freeze–thaw cycles.

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

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