Access to chiral α-substituted-β-hydroxy arylphosphonates enabled by biocatalytic dynamic reductive kinetic resolution-Reference-Cited by-同舟云学术

Access to chiral α-substituted-β-hydroxy arylphosphonates enabled by biocatalytic dynamic reductive kinetic resolution

Published:2020 Issue:14 Volume:18 Page:2672-2677
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Wang Zexu¹²³⁴⁵,Zeng Yiping⁶⁷⁸⁹¹⁰,Wu Xiaofan¹¹¹²⁹¹⁰,Li Zihan¹²³⁴⁵,Tao Yuan¹²³⁴⁵,Yu Xiaomin⁶⁷⁸⁹¹⁰,Huang Zedu¹²³⁴⁵^ORCID,Chen Fener¹²³⁴⁵

Affiliation:

1. Department of Chemistry

2. Engineering Center of Catalysis and Synthesis for Chiral Molecules

3. Fudan University

4. Shanghai Engineering Research Center of Industrial Asymmetric Catalysis of Chiral Drugs

5. Shanghai

6. FAFU-UCR Joint Center for Horticultural Biology and Metabolomics

7. Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology

8. Fujian Agriculture and Forestry University

9. Fuzhou

10. P. R. China

11. College of Chemical Engineering

12. Fuzhou University

Abstract

A ketoreductase (KRED)-catalyzed dynamic reductive kinetic resolution process was developed for highly stereoselective and step-economic synthesis of chiral α-substituted-β-hydroxy arylphosphonates.

Funder

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB00379D

Reference37 articles.

1. Exploiting Enzymatic Dynamic Reductive Kinetic Resolution (DYRKR) in Stereocontrolled Synthesis

2. Recent Advances on Carbonyl Reductases for Dynamic Kinetic Resolution

3. Asymmetric Amination of α-Chiral Aliphatic Aldehydes via Dynamic Kinetic Resolution to Access Stereocomplementary Brivaracetam and Pregabalin Precursors

4. Biocatalysis in the Pharmaceutical Industry: The Need for Speed

5. Role of Biocatalysis in Sustainable Chemistry

Cited by 11 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Ketoreductase-catalyzed dynamic reductive kinetic resolution of sterically hindered 2-aryl-1,5-benzothiazepin-3,4(2H,5H)-diones: asymmetric synthesis of a key diltiazem precursor and its analogues;Green Chemistry;2024

2. Biocatalysis for the selective reduction of carbonyl groups;Biocatalysis in Asymmetric Synthesis;2024

3. Light/air-induced direct oxyphosphinylation of terminal alkynes with diarylphosphine oxides toward β-ketophosphine oxides;Tetrahedron Letters;2023-12

4. Ketoreductase Catalyzed (Dynamic) Kinetic Resolution for Biomanufacturing of Chiral Chemicals;Frontiers in Bioengineering and Biotechnology;2022-06-30

5. Development of an engineered ketoreductase with improved activity, stereoselectivity and relieved substrate inhibition for enantioselective synthesis of a key (R)-α-lipoic acid precursor;Molecular Catalysis;2022-04