Access to chiral α-substituted-β-hydroxy arylphosphonates enabled by biocatalytic dynamic reductive kinetic resolution

Author:

Wang Zexu12345,Zeng Yiping678910,Wu Xiaofan1112910,Li Zihan12345,Tao Yuan12345,Yu Xiaomin678910,Huang Zedu12345ORCID,Chen Fener12345

Affiliation:

1. Department of Chemistry

2. Engineering Center of Catalysis and Synthesis for Chiral Molecules

3. Fudan University

4. Shanghai Engineering Research Center of Industrial Asymmetric Catalysis of Chiral Drugs

5. Shanghai

6. FAFU-UCR Joint Center for Horticultural Biology and Metabolomics

7. Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology

8. Fujian Agriculture and Forestry University

9. Fuzhou

10. P. R. China

11. College of Chemical Engineering

12. Fuzhou University

Abstract

A ketoreductase (KRED)-catalyzed dynamic reductive kinetic resolution process was developed for highly stereoselective and step-economic synthesis of chiral α-substituted-β-hydroxy arylphosphonates.

Funder

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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