Development of an engineered ketoreductase with improved activity, stereoselectivity and relieved substrate inhibition for enantioselective synthesis of a key (R)-α-lipoic acid precursor-Reference-Cited by-同舟云学术

Development of an engineered ketoreductase with improved activity, stereoselectivity and relieved substrate inhibition for enantioselective synthesis of a key (R)-α-lipoic acid precursor

Published:2022-04 Issue: Volume:522 Page:112208
ISSN:2468-8231
Container-title:Molecular Catalysis
language:en
Short-container-title:Molecular Catalysis

Author:

Hu Chen,Ye Baijun,Huang Zedu,Chen Fener

Funder

National Natural Science Foundation of China

Ministry of Science and Technology of the People's Republic of China

Science and Technology Commission of Shanghai Municipality

Publisher

Elsevier BV

Subject

Physical and Theoretical Chemistry,Process Chemistry and Technology,Catalysis

Reference44 articles.

1. Lipoic acid;Ramachanderan;Chem.Texts,2019

2. Syntheses of DL-α-lipoic acid;Reed;J. Am. Chem. Soc.,1955

3. Effect of lipoic acid on cyclophosphamide-induced diabetes and insulitis in nonobese diabetic mice;Faust;Int. J. Immunopharmacol.,1994

4. Thioctic (lipoic) acid - a therapeutic metal-chelating antioxidant;Ou;Biochem. Pharmacol.,1995

5. Treatment of alcohol-related liver-disease with thioctic acid - a 6 month randomized double-blind trial;Marshall;Gut,1982

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