Highly regioselective and diastereoselective synthesis of novel pyrazinoindolones<i>via</i>a base-mediated Ugi-<i>N</i>-alkylation sequence-Reference-Cited by-同舟云学术

Highly regioselective and diastereoselective synthesis of novel pyrazinoindolonesviaa base-mediated Ugi-N-alkylation sequence

Published:2023 Issue:25 Volume:13 Page:16963-16969
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Tajik Maryam¹,Shiri Morteza¹^ORCID,Hussain Faiq H. S.²^ORCID,Lotfi Nosood Yazdanbakhsh¹,Baeiszadeh Behnaz¹,Amini Zahra¹,Bikas Rahman³^ORCID,Pyra Anna⁴

Affiliation:

1. Department of Organic Chemistry, Faculty of Chemistry, Alzahra University, Vanak, Tehran 1993893973, Iran

2. Medical Analysis Department, Applied Science Faculty, Tishk International University, Erbil, Kurdistan Region, Iraq

3. Department of Chemistry, Faculty of Science, Imam Khomeini International University, Qazvin 34148-96818, Iran

4. Faculty of Chemistry, University of Wrocław, 14 Joliot-Curie, 50-383 Wroclaw, Poland

Abstract

An efficient base-mediated/metal-free approach has been developed for the synthesis of 1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-3-carboxamide derivativesviaintramolecular indole N–H alkylation of novel bis-amide Ugi-adducts.

Funder

Al Zahra University

Iran National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA02065G

Reference61 articles.

1. Heterocyclic Anticancer Compounds: Recent Advances and the Paradigm Shift towards the Use of Nanomedicine’s Tool Box

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4. A convenient synthesis of chiral amino acid derived 3,4-dihydro-2H-benzo[b][1,4]thiazines and antibiotic levofloxacin

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