1. 1,4-Benzothiazines (a) as anti-inflammatory agents: (i) Lombardino, J. G.; Wiseman, E. H. Med. Res. Rev. 1982, 2, 127; (ii) Turk, C. F. J. Med. Chem. 1973, 16, 776. (b) as anti-hypertensive agents: (i) Prasad, R. N. J. Med. Chem. 1969, 12, 290; (ii) Cecchetti, V.; Fravolini, A.; Schiaffella, F.; DeRegis, M.; Orzalesi, G.; Volpato, I. Farmaco. Ed. Sci. 1983, 38, 35. (c) As anti-cancer agents: (i) Gupta, R. R.; Dev, P. K.; Sharma, M. L.; Rajoria, C. M.; Gupta, A.; Nyati, M. Anticancer Drugs 1993, 4, 589; (ii) Todorov, D. K.; Ilarionova, M. V.; Gupta, R. R.; Molnar, J.; Motohashi, N. Heterocycl. Commun. 1995, 1, 153. (d) as anti-fungal agent: (i) Schiaffella, F.; Macchiarulo, A.; Milanese, L.; Vecchiarell, A.; Fringuell. R. Bioorg. Med. Chem. 2006, 14, 5196; (ii) Fringuelli , R .; Schiaffella, F.; Bistoni, F.; Pitzurra, L.; Vecchiarelli, A. Bioorg. Med. Chem. 1998, 6, 103. (e) as anti-tumour agent: (i) Coughlin, S. A.; Danz, D. W.; Robinson, R. G.; Klingbeil, K. M.; Wentland, M. P.; Corbett, T. H.; Waud, W. R.; Zwelling, L. A.; Altsschuler, E. Biochem. Pharmacol. 1995, 50, 111. (ii) Hasegawa, K.; Ito, S.; Inoue, S.; Wakamatsu, K.; Ozeki, H.; Ishiguro, I. Biochem. Pharmacol. 1997, 53, 1435. (iii) Inoue, S.; Hasegawa, K.; Wakamatsu, K.; Ito, S. Melanoma Res. 1998, 8, 105. (f) as KATP-Channel Openers (i) Cecchetti, V.; Calderone, V.; Tabarrini, O.; Sabatini, S.; Filipponi, E.; Testai, L.; Spogli, R.; Martinotti, E.; Fravolini, A. J. Med. Chem. 2003, 46, 3670. (g) as anti-HIV agent: (i) Grandolini. G;, Perioli.L;, Ambarogi. V. Eur. J. Med. Chem. 1999, 34, 701; h) as CETP inhibitors: (i) Kuo, G.; Wang, A.; Rano, T.; Prouty, C.; Demarest, K. T.; Pelton, P. US patent, 2007, WO/134149.
2. Continuous optical resolution of antihypertensive drug by column chromatography.
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4. 1,4-Benzothiazine and 1,4-Benzoxazine imidazole derivatives with antifungal activity: A docking study
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