Affiliation:
1. Department of Chemistry, ABN Seal College, Cooch Behar, 736101, India
2. Department of Chemistry, Cotton University,
Guwahati, 781003, India
Abstract
Abstract:
Heterocyclic moieties are ubiquitous in nature and the exploration of heterocyclic chemistry
goes centuries back, which have coalesced into the invention of greener methodologies towards
the synthesis of heterocycles of potential uses. Benzothiazine is an important class of heterocyclic
molecule, in which a benzene ring is fused with a six–member N, S containing ring.
Amongst the three possible isomers, 1,4–benzothiazines show a wide spectrum of pharmaceutical
and biological activities like anti–inflammatory, anti–rheumatic, antihypertensive, andantipathogenic
roles. In search of greener protocols,metal–free catalysts, and environmentally benign reaction
conditions, a lot have been unboxed to date, and many other dimensions remain yet to be deciphered.
This minireview is an attempt to classify various sustainable protocols for the synthesis
of 1,4–benzothiazine scaffolds over the last decade based on the reacting components and pathways,
along with the consideration of plausible mechanistic insights and critical analysis.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Analytical Chemistry,Catalysis
Cited by
4 articles.
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