Validation of a homology model of Mycobacterium tuberculosis DXS: rationalization of observed activities of thiamine derivatives as potent inhibitors of two orthologues of DXS-Reference-Cited by-同舟云学术

Validation of a homology model of Mycobacterium tuberculosis DXS: rationalization of observed activities of thiamine derivatives as potent inhibitors of two orthologues of DXS

Published:2015 Issue:46 Volume:13 Page:11263-11277
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Masini T.¹²³⁴,Lacy B.⁵⁶⁷⁸⁹,Monjas L.¹²³⁴,Hawksley D.¹⁰¹¹¹²¹³,de Voogd A. R.¹²³⁴,Illarionov B.¹⁴¹⁵¹⁶¹⁷,Iqbal A.¹⁰¹¹¹²¹³,Leeper F. J.¹⁰¹¹¹²¹³,Fischer M.¹⁴¹⁵¹⁶¹⁷,Kontoyianni M.⁵⁶⁷⁸⁹,Hirsch A. K. H.¹²³⁴

Affiliation:

1. Stratingh Institute for Chemistry

2. University of Groningen

3. 9747 AG Groningen

4. The Netherlands

5. Department of Pharmaceutical Sciences

6. School of Pharmacy

7. Southern Illinois University Edwardsville

8. Edwardsville

9. USA

10. Department of Chemistry

11. University of Cambridge

12. Cambridge

13. UK

14. Hamburg School of Food Science

15. Institute of Food Chemistry

16. Hamburg

17. Germany

Abstract

We present the a homology model ofM. tuberculosisDXS that we validated by identifying thiamine and thiamine diphosphate analogues as potent inhibitors of DXS.

Funder

Cambridge Commonwealth Trust

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB01666E

Reference68 articles.

1. World Health Organization

2. World Health Organization

3. Extensive Drug Resistance in Malaria and Tuberculosis