Design of thiamine analogues for inhibition of thiamine diphosphate (ThDP)-dependent enzymes: Systematic investigation through Scaffold-Hopping and C2-Functionalisation-Reference-Cited by-同舟云学术

Design of thiamine analogues for inhibition of thiamine diphosphate (ThDP)-dependent enzymes: Systematic investigation through Scaffold-Hopping and C2-Functionalisation

Published:2023-09 Issue: Volume:138 Page:106602
ISSN:0045-2068
Container-title:Bioorganic Chemistry
language:en
Short-container-title:Bioorganic Chemistry

Author:

Chan Alex H.Y.,Ho Terence C.S.,Irfan Rimsha,Hamid Rawia A.A.,Rudge Emma S.,Iqbal Amjid,Turner Alex,Hirsch Anna K.H.,Leeper Finian J.^ORCID

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference66 articles.

1. Supplementary thiamine is still important in alcohol dependence;Rees;Alcohol Alcohol.,2013

2. Thiamine triphosphate: a ubiquitous molecule in search of a physiological role;Bettendorff;Metab. Brain Dis.,2014

3. Analysis of the Protein Binding Sites for Thiamin and Its Derivatives to Elucidate the Molecular Mechanisms of the Noncoenzyme Action of Thiamin (Vitamin B1);Bunik;Stud. Nat. Prod. Chem.,2017

4. Structure, mechanism and catalytic duality of thiamine-dependent enzymes;Frank;Cell. Mol. Life Sci.,2007

5. Communication between Thiamin Cofactors in the Escherichia coli Pyruvate Dehydrogenase Complex E1 Component Active Centers: Evidence for a “Direct Pathway” between the 4’-Aminopyrimidine N1’ Atoms;Nemeria;J. Biol. Chem.,2010

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Identification and characterization of thiamine analogues with antiplasmodial activity;2024-07-20

2. Thiamine analogues featuring amino-oxetanes as potent and selective inhibitors of pyruvate dehydrogenase;Bioorganic & Medicinal Chemistry Letters;2024-01

3. Evaluation of ketoclomazone and its analogues as inhibitors of 1-deoxy-d-xylulose 5-phosphate synthases and other thiamine diphosphate (ThDP)-dependent enzymes;RSC Medicinal Chemistry;2024

4. Open-chain thiamine analogues as potent inhibitors of thiamine pyrophosphate (TPP)-dependent enzymes;Organic & Biomolecular Chemistry;2023