Open-chain thiamine analogues as potent inhibitors of thiamine pyrophosphate (TPP)-dependent enzymes-Reference-Cited by-同舟云学术

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Open-chain thiamine analogues as potent inhibitors of thiamine pyrophosphate (TPP)-dependent enzymes

Published:2023 Issue:32 Volume:21 Page:6531-6536
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Chan Alex H. Y.¹^ORCID,Ho Terence C. S.¹,Leeper Finian J.¹^ORCID

Affiliation:

1. Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK

Abstract

Flexible open-chain analogues of thiamine can occupy various different pockets in pyruvate dehydrogenase E1 subunit, depending on whether they have a metal-binding group or not.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB00884C

Reference33 articles.

1. Structure, mechanism and catalytic duality of thiamine-dependent enzymes

2. Inhibition of thiamin diphosphate dependent enzymes by 3-deazathiamin diphosphate

3. Synthesis and biological evaluation of pyrophosphate mimics of thiamine pyrophosphate based on a triazole scaffold

4. Prodrug thiamine analogs as inhibitors of the enzyme transketolase

5. Non-charged thiamine analogs as inhibitors of enzyme transketolase

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Evaluation of ketoclomazone and its analogues as inhibitors of 1-deoxy-d-xylulose 5-phosphate synthases and other thiamine diphosphate (ThDP)-dependent enzymes;RSC Medicinal Chemistry;2024

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