Evaluation of ketoclomazone and its analogues as inhibitors of 1-deoxy-<scp>d</scp>-xylulose 5-phosphate synthases and other thiamine diphosphate (ThDP)-dependent enzymes-Reference-Cited by-同舟云学术

Evaluation of ketoclomazone and its analogues as inhibitors of 1-deoxy-d-xylulose 5-phosphate synthases and other thiamine diphosphate (ThDP)-dependent enzymes

Published:2024 Issue:5 Volume:15 Page:1773-1781
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Chan Alex H. Y.¹^ORCID,Ho Terence C. S.¹,Fathoni Imam²,Hamid Rawia³⁴^ORCID,Hirsch Anna K. H.³⁴,Saliba Kevin J.²^ORCID,Leeper Finian J.¹^ORCID

Affiliation:

1. Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK

2. Research School of Biology, The Australian National University, Canberra, ACT, 2601, Australia

3. Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) – Helmholtz Centre for Infection Research (HZI), Campus Building E8.1, 66123 Saarbrücken, Germany

4. Department of Pharmacy, Saarland University, Campus Building E8.1, 66123 Saarbrücken, Germany

Abstract

Most pathogenic bacteria, apicomplexan parasites and plants rely on the methylerythritol phosphate (MEP) pathway to obtain precursors of isoprenoids.

Funder

Helmholtz Association

Schlumberger Foundation

European Research Council

Australian Government

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00083H