High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of <i>Plasmodium falciparum</i>-Reference-Cited by-同舟云学术

High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of Plasmodium falciparum

Published:2024-02-17 Issue:3 Volume:10 Page:1000-1022
ISSN:2373-8227
Container-title:ACS Infectious Diseases
language:en
Short-container-title:ACS Infect. Dis.

Author:

Johannsen Sandra¹²^ORCID,Gierse Robin M.¹²³,Krüger Arne⁴,Edwards Rachel L.⁵,Nanna Vittoria¹^ORCID,Fontana Anna¹,Zhu Di¹³,Masini Tiziana³,de Carvalho Lais Pessanha⁶^ORCID,Poizat Mael⁷,Kieftenbelt Bart⁷,Hodge Dana M.⁸,Alvarez Sophie⁹,Bunt Daan³^ORCID,Lacour Antoine¹²,Shams Atanaz¹²,Meissner Kamila Anna⁴,de Souza Edmarcia Elisa⁴,Dröge Melloney⁷,van Vliet Bernard⁷,den Hartog Jack⁷,Hutter Michael C.¹⁰^ORCID,Held Jana⁶¹¹¹²,Odom John Audrey R.⁸^ORCID,Wrenger Carsten⁴^ORCID,Hirsch Anna K. H.¹²³^ORCID

Affiliation:

1. Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) − Helmholtz Centre for Infection Research (HZI), Campus Building E8.1, Saarbrücken 66123, Germany

2. Department of Pharmacy, Saarland University, Campus Building E8.1, Saarbrücken 66123, Germany

3. Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 7, Groningen 9747 AG, The Netherlands

4. Unit for Drug Discovery, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1374, São Paulo-SP 05508-000, Brazil

5. Department of Pediatrics, Washington University School of Medicine, Saint Louis, Missouri 63110, United States

6. Institute of Tropical Medicine, University of Tübingen, Wilhelmstraße 27, Tübingen 72074, Germany

7. Symeres, Kadijk 3, Groningen 9747 AT, The Netherlands

8. Department of Pediatrics, Children’s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States

9. Proteomics & Metabolomics Facility, Center for Biotechnology, Department of Agronomy and Horticulture, University of Nebraska-Lincoln, Lincoln, Nebraska 68588, United States

10. Center for Bioinformatics, Saarland University, Campus Building E2.1, Saarbrücken 66123, Germany

11. German Center for Infection Research (DZIF), Partner Site Tübingen, Tübingen 72074, Germany

12. Centre de Recherches Médicales de Lambaréné (CERMEL), B.P. 242 Lambaréné, Gabon

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Funda????o de Amparo ?? Pesquisa do Estado de S??o Paulo

Helmholtz Association

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.3c00670

Reference67 articles.

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