Genetically-encoded discovery of proteolytically stable bicyclic inhibitors for morphogen NODAL-Reference-Cited by-同舟云学术

Genetically-encoded discovery of proteolytically stable bicyclic inhibitors for morphogen NODAL

Published:2021 Issue:28 Volume:12 Page:9694-9703
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Wong Jeffrey Y.-K.¹²³⁴^ORCID,Mukherjee Raja¹²³⁴,Miao Jiayuan¹⁵⁶⁷^ORCID,Bilyk Olena⁸²³⁴,Triana Vivian¹²³⁴,Miskolzie Mark¹²³⁴,Henninot Antoine⁹¹⁰⁷,Dwyer John J.⁹¹⁰⁷,Kharchenko Serhii¹¹¹²¹³,Iampolska Anna¹¹¹²¹³,Volochnyuk Dmitriy M.¹¹¹²¹³,Lin Yu-Shan¹⁵⁶⁷^ORCID,Postovit Lynne-Marie⁸²³⁴,Derda Ratmir¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. University of Alberta

3. Edmonton

4. Canada

5. Tufts University

6. Medford

7. USA

8. Department of Experimental Oncology

9. Ferring Research Institute

10. San Diego

11. Enamine Ltd.

12. Kyiv 02094

13. Ukraine

Abstract

A two-fold symmetric linchpin (TSL) converts readily available phage-displayed disulfide peptide libraries to proteolytically stable bicyclic peptides. The bicyclic phage library was screened to discover an antagonist of NODAL morphogen.

Funder

Ferring Research Institute

Natural Sciences and Engineering Research Council of Canada

Canadian Institutes of Health Research

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC01916C

Reference87 articles.