Structure–Activity Relationship and Molecular Mechanics Reveal the Importance of Ring Entropy in the Biosynthesis and Activity of a Natural Product
Author:
Affiliation:
1. Department of Biology, California Institute for Biomedical Research, La Jolla, California 92037, United States
2. Chemistry, Engineering, and Medicine for Human Health (ChEM-H), Stanford University, Stanford, California 94305, United States
Funder
U.S. Department of Health and Human Services
Publisher
American Chemical Society (ACS)
Subject
Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis
Link
https://pubs.acs.org/doi/pdf/10.1021/jacs.6b10792
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1. Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin
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4. Follow the leader: the use of leader peptides to guide natural product biosynthesis
5. Three Ring Posttranslational Circuses: Insertion of Oxazoles, Thiazoles, and Pyridines into Protein-Derived Frameworks
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