Self-optimisation of the final stage in the synthesis of EGFR kinase inhibitor AZD9291 using an automated flow reactor-Reference-Cited by-同舟云学术

登录注册会员服务联系我们

Self-optimisation of the final stage in the synthesis of EGFR kinase inhibitor AZD9291 using an automated flow reactor

Published:2016 Issue:4 Volume:1 Page:366-371
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Holmes Nicholas¹²³⁴⁵,Akien Geoffrey R.¹²³⁴⁵,Blacker A. John¹²³⁴⁵,Woodward Robert L.⁶⁷⁵,Meadows Rebecca E.⁶⁷⁵,Bourne Richard A.¹²³⁴⁵

Affiliation:

1. Institute of Process Research and Development

2. School of Chemistry

3. University of Leeds

4. Leeds

5. UK

6. AstraZeneca Pharmaceutical Development

7. Macclesfield

Abstract

Self-optimising flow reactors combine online analysis with evolutionary feedback algorithms to rapidly achieve optimum conditions.

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RE/C6RE00059B

Reference38 articles.

1. A Simplified Process for the Manufacture of AZD0530, a Potent SRC Kinase Inhibitor

2. Synthesis of the NK1 Receptor Antagonist GW597599. Part 1: Development of a Scalable Route to a Key Chirally Pure Arylpiperazine

3. Development of a Second-Generation, Highly Efficient Manufacturing Route for the HIV Integrase Inhibitor Raltegravir Potassium

4. Development of a Practical and Efficient Synthesis of CP-945,598-01, a CB1 Antagonist for the Treatment of Obesity

5. The Large-Scale Synthesis of (S)-N-Boc-bis(4-fluorophenyl)alanine

Cited by 95 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Self-Driving Laboratories for Chemistry and Materials Science;Chemical Reviews;2024-08-13

2. Self-Optimizing Flow Reactions for Sustainability: An Experimental Bayesian Optimization Study;ACS Sustainable Chemistry & Engineering;2024-06-19

3. Automated kinetics measurement for homogeneous photocatalytic reactions in continuous microflow;Artificial Intelligence Chemistry;2024-06

4. Expanding analytical horizons: 3D HPLC calibration surfaces for micromole scale self-optimizing flow reactors;Reaction Chemistry & Engineering;2024

5. A machine learning-enabled process optimization of ultra-fast flow chemistry with multiple reaction metrics;Reaction Chemistry & Engineering;2024

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号京ICP备18003416号-3