Development of a Second-Generation, Highly Efficient Manufacturing Route for the HIV Integrase Inhibitor Raltegravir Potassium-Reference-Cited by-同舟云学术

Development of a Second-Generation, Highly Efficient Manufacturing Route for the HIV Integrase Inhibitor Raltegravir Potassium

Published:2010-11-16 Issue:1 Volume:15 Page:73-83
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Humphrey Guy R.¹,Pye Philip J.¹,Zhong Yong-Li¹,Angelaud Remy¹,Askin David¹,Belyk Kevin M.¹,Maligres Peter E.¹,Mancheno Danny E.¹,Miller Ross A.¹,Reamer Robert A.¹,Weissman Steven A.¹

Affiliation:

1. Department of Process Research, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op100257r

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4. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents.Panel on Antiretroviral Guidelines for Adults and Adolescents;U.S. Department of Health and Human Services. December 1, 2009; pp1−161. Available athttp://www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf.

5. Discovery of Raltegravir, a Potent, Selective Orally Bioavailable HIV-Integrase Inhibitor for the Treatment of HIV-AIDS Infection

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