Structural analysis of anti-retroviral drug raltegravir and its potential impurity C: investigation of solubility and stability-Reference-Cited by-同舟云学术

Structural analysis of anti-retroviral drug raltegravir and its potential impurity C: investigation of solubility and stability

Published:2024 Issue:4 Volume:26 Page:517-531
ISSN:1466-8033
Container-title:CrystEngComm
language:en
Short-container-title:CrystEngComm

Author:

Fayaz T. K. S.¹^ORCID,Chanduluru Hemanth Kumar²,Lal Puja³,Ghosh Animesh³^ORCID,Chernyshev Vladimir⁴⁵^ORCID,Sanphui Palash¹^ORCID

Affiliation:

1. Department of Chemistry, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamil Nadu 603203, India

2. SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamil Nadu 603203, India

3. Solid State Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, Ranchi – 835215, Jharkhand, India

4. Department of Chemistry, M. V. Lomonosov Moscow State University, 1-3 Leninskie Gory, Moscow 119991, Russian Federation

5. A. N. Frumkin Institute of Physical Chemistry and Electrochemistry RAS, 31 Leninsky Prospect, Moscow 119071, Russian Federation

Abstract

An anhydrous form of raltegravir and two crystalline phases of its impurity C were obtained during solid form screening and their crystal structures are reported with variable conformations.

Funder

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CE/D3CE01071F

Reference31 articles.

1. Polymorphism and Solvatomorphism 2010

2. First Evidence of Polymorphism in Furosemide Solvates

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4. Polymorph Screening of the Antitumor Drug Ripretinib─Selective Preference of Dimer Synthons

5. Identification, Synthesis, and Strategy For Minimization of Potential Impurities Observed In Raltegravir Potassium Drug Substance

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