Development of a Practical and Efficient Synthesis of CP-945,598-01, a CB1 Antagonist for the Treatment of Obesity-Reference-Cited by-同舟云学术

Development of a Practical and Efficient Synthesis of CP-945,598-01, a CB1 Antagonist for the Treatment of Obesity

Published:2008-12-22 Issue:2 Volume:13 Page:186-197
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Ragan John A.¹,Bourassa Dennis E.¹,Blunt Jon¹,Breen Darragh¹,Busch Frank R.¹,Cordi Eric M.¹,Damon David B.¹,Do Nga¹,Engtrakul Alanya¹,Lynch Denis¹,McDermott Ruth E.¹,Mongillo Joseph A.¹,O’Sullivan Maria M.¹,Rose Peter R.¹,Vanderplas Brian C.¹

Affiliation:

1. Chemical Research and Development, Materials Science, and Analytical Research and Development, Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06335, U.S.A., Supply Chain, Pfizer Ltd., Ramsgate Road, Sandwich, Kent CT139NJ, U.K., and Pfizer Global Manufacturing, Ringaskiddy API Plant, County Cork, Ireland

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op800255j

Reference16 articles.

1. The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance

2. Regulation, Function, and Dysregulation of Endocannabinoids in Models of Adipose and β-Pancreatic Cells and in Obesity and Hyperglycemia

3. Activation of the Peripheral Endocannabinoid System in Human Obesity

4. The CB1 receptor antagonist rimonabant reverses the diet‐induced obesity phenotype through the regulation of lipolysis and energy balance

5. The cannabinoid CB1 receptor inverse agonist, rimonabant, modifies body weight and adiponectin function in diet-induced obese rats as a consequence of reduced food intake

Cited by 17 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Large-Scale Amidations in Process Chemistry: Practical Considerations for Reagent Selection and Reaction Execution;Organic Process Research & Development;2022-06-07

2. Process Optimization;Handbook for Chemical Process Research and Development;2016-10-17

3. Solid Form;Handbook for Chemical Process Research and Development;2016-10-17

4. Pharmaceutical Salts;Handbook for Chemical Process Research and Development;2016-10-17

5. Design of New Synthetic Route;Handbook for Chemical Process Research and Development;2016-10-17