Synthesis, docking studies and in vitro evaluation of novel chalcones as potent inhibitors of phosphodiesterase 5 from human platelets and 5A from bovine recombinant-Reference-Cited by-同舟云学术

Synthesis, docking studies and in vitro evaluation of novel chalcones as potent inhibitors of phosphodiesterase 5 from human platelets and 5A from bovine recombinant

Published:2018 Issue:17 Volume:42 Page:14365-14385
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Sherikar Amol S.¹²³⁴^ORCID,Dhavale Rakesh P.¹⁵⁶⁴^ORCID,Bhatia Manish S.¹⁵⁶⁴^ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry

2. Tatyasaheb Kore College of Pharmacy

3. Dist-Kolhapur-416 113

4. India

5. Bharati Vidyapeeth College of Pharmacy, Kolhapur

6. Kolhapur-416 013

Abstract

Chalcones with a nitric oxide (NO) donating scaffold and a variety of substituents were synthesized. A docking study was performed and molecules were evaluated for in vitro phosphodiesterase 5 and 5A inhibitory potency.

Funder

All India Council for Technical Education

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/NJ/C8NJ02077A

Reference35 articles.

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