The synthesis of a novel pentoxifylline derivative with superior human sperm motility enhancement properties-Reference-Cited by-同舟云学术

The synthesis of a novel pentoxifylline derivative with superior human sperm motility enhancement properties

Published:2021 Issue:2 Volume:45 Page:1072-1081
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Kumari Sandhya¹²³⁴³,Kotyan Sukumar⁵⁶⁷⁸⁹^ORCID,Sugunan Sinoy¹⁰¹¹¹²⁹^ORCID,Rajanikant G. K.¹⁰¹¹¹²⁹,Kumar Kothanahally S. Sharath¹³¹⁴¹⁵⁹,Adiga Satish Kumar¹²³⁴³,Dasappa Jagadeesh Prasad⁵⁶⁷⁸⁹,Kalthur Guruprasad¹²³⁴³^ORCID

Affiliation:

1. Department of Clinical Embryology

2. Kasturba Medical College of Manipal

3. Manipal

4. Academy of Higher Education

5. Department of Chemistry

6. Mangalore University

7. Mangalagangothri

8. Mangalore

9. India

10. School of Biotechnology

11. National Institute of Technology Calicut

12. Calicut

13. Department of Studies in Chemistry

14. University of Mysore

15. Mysuru

Abstract

mPTF1 demonstrated lower genotoxicity, higher affinity for PDEs, & reasonable pharmacokinetic, druglikeness & ADMET properties compared to Pentoxifylline.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NJ/D0NJ03522J

Reference49 articles.

1. Regulation and function of cyclic nucleotides

2. Cyclic nucleotide research — still expanding after half a century

3. Central role of soluble adenylyl cyclase and cAMP in sperm physiology

4. Partial characterization of human spermatozoal phosphodiesterase and adenylate cyclase and the effect of steroids on their activities

5. Cyclic nucleotide phosphodiesterases in human spermatozoa and seminal fluid: Presence of an active PDE10A in human spermatozoa

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