Affiliation:
1. College of Pharmaceutical Science, Yunnan University of Chinese Medicine, Kunming 650500, China
Abstract
Background:
Infection is a global threat to human health, and there is an urgent need to develop
new effective antibacterial drugs to treat bacterial infections.
Objective:
To study the antibacterial activity of piperazine substituted chalcone sulphonamides.
Materials and Methods:
A series of novel piperazine substituted chalcone sulphonamides have been prepared,
and in vitro antibacterial activity against Staphylococcus aureus, Bacillus subtilis and Escherichia coli strains
were evaluated.
Results:
The results showed that derivatives 6a, 6c and 6h displayed good antibacterial activity against
Bacillus subtilis with MIC values of 4.0-8.0 mg/mL.
Conclusion:
Piperazine substituted chalcone sulphonamides may be used as potential antibacterial agents.
Funder
National Natural Science Foundation of China
Yunnan Provincial Science and Technology Department
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry
Cited by
8 articles.
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