Radiosynthesis and evaluation of a fluorine-18 radiotracer [18F]FS1P1 for imaging sphingosine-1-phosphate receptor 1-Reference-Cited by-同舟云学术

Radiosynthesis and evaluation of a fluorine-18 radiotracer [18F]FS1P1 for imaging sphingosine-1-phosphate receptor 1

Published:2022 Issue:5 Volume:20 Page:1041-1052
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Qiu Lin¹^ORCID,Jiang Hao¹,Yu Yanbo¹^ORCID,Gu Jiwei¹,Wang Jinzhi¹,Zhao Haiyang¹,Huang Tianyu¹,Gropler Robert J.¹,Klein Robyn S.²³⁴,Perlmutter Joel S.³⁵⁶,Tu Zhude¹^ORCID

Affiliation:

1. Department of Radiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA

2. Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri 63110, USA

3. Departments of Neuroscience, Washington University School of Medicine, Saint Louis, MO 63110, USA

4. Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA

5. Department of Neurology, Washington University School of Medicine, Saint Louis, MO 63110, USA

6. Physical Therapy and Occupational Therapy, Washington University School of Medicine, Saint Louis, MO, 63110, USA

Abstract

A promising sphingosine-1-phosphate receptor 1 PET radiotracer [18F]FS1P1 was synthesized using a facile multiple step F-18 radiochemistry procedure.

Funder

National Institute of Biomedical Imaging and Bioengineering

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D1OB02225C

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