Synthesis and anticancer activity of silver(i)–N-heterocyclic carbene complexes derived from the natural xanthine products caffeine, theophylline and theobromine-Reference-Cited by-同舟云学术

Synthesis and anticancer activity of silver(i)–N-heterocyclic carbene complexes derived from the natural xanthine products caffeine, theophylline and theobromine

Published:2015 Issue:16 Volume:44 Page:7563-7569
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Mohamed Heba A.¹²³⁴,Lake Benjamin R. M.¹²³⁴,Laing Thomas⁵⁶⁷⁴,Phillips Roger M.⁸⁹¹⁰⁴,Willans Charlotte E.¹²³⁴

Affiliation:

1. School of Chemistry

2. University of Leeds

3. Leeds

4. UK

5. Institute of Cancer Therapeutics

6. University of Bradford

7. Bradford

8. Department of Pharmacy

9. University of Huddersfield

10. Huddersfield

Abstract

Silver–N-heterocyclic carbene complexes derived from natural xanthine products have been prepared. Chemosensitivity studies indicate a correlation between cytotoxicity, ligand sterics and hydrophilicity.

Funder

University Of Leeds

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/DT/C4DT03679D

Reference23 articles.

1. A stable crystalline carbene

2. N-Heterocyclic Carbenes: A New Concept in Organometallic Catalysis

3. NHC–Ru complexes—Friendly catalytic tools for manifold chemical transformations