Synthesis, photophysical characterisation, quantum-chemical study and <i>in vitro</i> antiproliferative activity of cyclometalated Ir(<scp>iii</scp>) complexes based on 3,5-dimethyl-1-phenyl-1<i>H</i>-pyrazole and N,N-donor ligands-Reference-Cited by-同舟云学术

Synthesis, photophysical characterisation, quantum-chemical study and in vitro antiproliferative activity of cyclometalated Ir(iii) complexes based on 3,5-dimethyl-1-phenyl-1H-pyrazole and N,N-donor ligands

Published:2024 Issue:34 Volume:53 Page:14438-14450
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Masternak Joanna¹^ORCID,Okła Karol¹^ORCID,Kubas Adam²^ORCID,Voller Jiří³,Kozlanská Karolína³,Zienkiewicz-Machnik Małgorzata²^ORCID,Gilewska Agnieszka¹,Sitkowski Jerzy⁴⁵,Kamecka Anna⁶,Kazimierczuk Katarzyna⁷^ORCID,Barszcz Barbara¹^ORCID

Affiliation:

1. Institute of Chemistry, Jan Kochanowski University in Kielce, Uniwersytecka 7, 25-406 Kielce, Poland

2. Institute of Physical Chemistry, Polish Academy of Sciences, Marcina Kasprzaka 44/52, 01-224 Warsaw, Poland

3. Department of Experimental Biology, Faculty of Science, Palacký University, Šlechtitelů 11, 783 71 Olomouc, Czech Republic

4. Institute of Organic Chemistry, Polish Academy of Sciences, Marcina Kasprzaka 44/52, 01-224 Warsaw, Poland

5. National Medicines Institute, Chełmska 30/34, 00-725 Warsaw, Poland

6. Faculty of Sciences, University of Siedlce, 3-Maja 54, 08-110 Siedlce, Poland

7. Faculty of Chemistry, Gdańsk University of Technology, Gabriela Narutowicza 11/12, 80-233 Gdańsk, Poland

Abstract

Cyclometalated complexes of Ir(iii) and phenyl-1H-pyrazole derivatives with N^N auxiliary ligands have been synthesised and fully characterised physicochemically. The resulting complexes exhibit interesting luminescence and are highly potent cytotoxic.

Funder

Uniwersytet Jana Kochanowskiego w Kielcach

Politechnika Gdańska

Ministerstwo Nauki i Szkolnictwa Wyższego

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/DT/D4DT01796J

Reference45 articles.

1. Cyclometalated iridium(III) luminescent complexes in therapy and phototherapy

2. Multi-phase microstructures drive exciton dissociation in neat semicrystalline polymeric semiconductors

3. Emissive bis-tridentate Ir(III) metal complexes: Tactics, photophysics and applications

4. High-affinity sequence-selective DNA binding by iridium(iii) polypyridyl organometallopeptides

5. Somatostatin receptor-targeted organometallic iridium(iii) complexes as novel theranostic agents