High-affinity sequence-selective DNA binding by iridium(iii) polypyridyl organometallopeptides-Reference-Cited by-同舟云学术

High-affinity sequence-selective DNA binding by iridium(iii) polypyridyl organometallopeptides

Published:2016 Issue:6 Volume:52 Page:1234-1237
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Gamba Ilaria¹²³⁴,Salvadó Iria¹²³⁴,Brissos Rosa F.⁵⁶⁷⁸⁴,Gamez Patrick⁵⁶⁷⁸⁴,Brea José⁹¹⁰²⁴,Loza María Isabel⁹¹⁰²⁴,Vázquez M. Eugenio¹¹²³⁴,López Miguel Vázquez¹²³⁴

Affiliation:

1. Departamento de Química Inorgánica and Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS)

2. Universidade de Santiago de Compostela

3. 15782 Santiago de Compostela

4. Spain

5. Departament de Química Inorgánica

6. QBI

7. Universitat de Barcelona

8. 08028 Barcelona

9. Grupo de Investigación BioFarma/Plataforma de Screening USEF

10. Centro de Investigación CIMUS

11. Departamento de Química Orgánica and Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS)

Abstract

We demonstrate the application of solid-phase peptide synthesis methods for assembling polynuclear Ir(iii) organometallopeptides that exhibit high DNA-binding affinity, sequence selectivity, and high cytotoxic effect towards a set of cancer cell lines.

Funder

European Research Council

Ministerio de Economía y Competitividad

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CC/C5CC07619F

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