Orange/red light emitting iridium(III) organometallic complexes containing 2,3‐di(pyridine‐2‐yl)quinoxaline as ancillary ligand and their anticancer properties

Author:

Pradhan Kahnu Charan1,Jadab Madhusmita1,Rout Smrutirekha2,Dandela Rambabu2,Mandal Deepa3,Parija Tithi3,Barik Sahadev4,Kumar Jagadish5,Pal Satyanarayan1

Affiliation:

1. Dept. of Chemistry, Utkal Uniersity Bhubaneswar Odisha 751013 India

2. Institute of Chemical Technology, Mumbai, Indianoil Odisha Campus Bhubaneswar Odisha 751013 India

3. School of Biotechnology Kalinga Institute of Industrial Technology Bhubaneswar Odisha 751024 India

4. School of Chemical Sciences National Institute of Science Education and Research Bhubaneswar Odisha 752050 India

5. Dept. of Physics Utkal University Bhubaneswar Odisha 751004 India

Abstract

AbstractA π‐electron rich ligand, 2,3‐di(pyridine‐2‐yl)quinoxaline, was introduced in Ir(III) coordination sphere along with four different cyclometallating ligands to obtain four new complexes (Ir1Ir4) of formula [Ir(C N)2(pyrquinox)]PF6 {where C N is monoanionic cyclometallating ligand; 2‐phenylpyridine (ppy), 2‐(2,4‐difluorophenyl)‐5‐(trifluoromethyl)pyridine (F2CF3ppy), 2,5‐diphenylbenzoxazole (phox), 2,3‐diphenylquinoxaline (phquinox) and pyrquinox=2,3‐di(pyridine‐2‐yl)quinoxaline}. Structure of Ir1 was determined from single crystal X‐ray structure analysis and found it to be a bis‐heteroleptic Ir(III) mononuclear octahedral complex of formula [Ir(ppy)2(pyrquinox)]PF6. A very same structural formulation of Ir2Ir4 was supported by different spectroscopic and analytical data. Theoretical calculations were helpful in understanding the optical and electrochemical properties of Ir1Ir4. The effect of rich π‐electrons ancillary ligand (pyrquinox) was observed on luminescence properties of the complexes, which on irradiation produced emissions in the orange and red spectral regions. The cytotoxic behaviours of Ir1Ir4 were explored against MCF‐7 cell line through MTT assays. The obtained IC50 values were found in low micromolar region (5–8 μM) and displayed comparatively higher cytotoxicity behaviour to cis‐platin.

Publisher

Wiley

Subject

Inorganic Chemistry

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