A strategy to disentangle direct and indirect effects on (de)phosphorylation by chemical modulators of the phosphatase PP1 in complex cellular contexts-Reference-Cited by-同舟云学术

A strategy to disentangle direct and indirect effects on (de)phosphorylation by chemical modulators of the phosphatase PP1 in complex cellular contexts

Published:2024 Issue:8 Volume:15 Page:2792-2804
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Hoermann Bernhard¹²^ORCID,Dürr Eva-Maria¹²^ORCID,Ludwig Christina³⁴^ORCID,Ercan Melda¹²,Köhn Maja¹²^ORCID

Affiliation:

1. Faculty of Biology, Institute of Biology III, University of Freiburg, Freiburg, Germany

2. Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany

3. Chair of Proteomics and Bioanalytics, Technical University of Munich (TUM), Freising, Germany

4. Bavarian Center for Biomolecular Mass Spectrometry (BayBioMS), Technical University of Munich (TUM), Freising, Germany

Abstract

This strategy identifies PP1 substrate candidates and pathways triggered by modulator treatment, offering a potentially broad applicability of this approach to other enzyme modulators.

Funder

H2020 European Research Council

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D3SC04746F

Reference59 articles.

1. A small-molecule PI3Kα activator for cardioprotection and neuroregeneration

2. Small-Molecule–Mediated Stabilization of PP2A Modulates the Homologous Recombination Pathway and Potentiates DNA Damage-Induced Cell Death

3. Direct AKT activation in tumor-infiltrating lymphocytes markedly increases interferon-γ (IFN-γ) for the regression of tumors resistant to PD-1 checkpoint blockade

4. Small-Molecule Activators of a Proenzyme

5. Activation of protein phosphatase 1 by a selective phosphatase disrupting peptide reduces sarcoplasmic reticulum Ca 2+ leak in human heart failure