A small-molecule PI3Kα activator for cardioprotection and neuroregeneration
Author:
Gong Grace Q.ORCID, Bilanges BenoitORCID, Allsop Ben, Masson Glenn R.ORCID, Roberton VictoriaORCID, Askwith Trevor, Oxenford Sally, Madsen Ralitsa R., Conduit Sarah E.ORCID, Bellini Dom, Fitzek Martina, Collier Matt, Najam Osman, He Zhenhe, Wahab Ben, McLaughlin Stephen H.ORCID, Chan A. W. Edith, Feierberg Isabella, Madin Andrew, Morelli Daniele, Bhamra Amandeep, Vinciauskaite VanesaORCID, Anderson Karen E.ORCID, Surinova SilviaORCID, Pinotsis NikosORCID, Lopez-Guadamillas Elena, Wilcox Matthew, Hooper Alice, Patel Chandni, Whitehead Maria A., Bunney Tom D.ORCID, Stephens Len R.ORCID, Hawkins Phillip T.ORCID, Katan MatildaORCID, Yellon Derek M., Davidson Sean M.ORCID, Smith David M.ORCID, Phillips James B.ORCID, Angell Richard, Williams Roger L.ORCID, Vanhaesebroeck BartORCID
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Reference91 articles.
1. Cowan-Jacob, S. W., Jahnke, W. & Knapp, S. Novel approaches for targeting kinases: allosteric inhibition, allosteric activation and pseudokinases. Future Med. Chem. 6, 541–561 (2014). 2. Astl, L., Tse, A. & Verkhivker, G. M. Interrogating regulatory mechanisms in signaling proteins by allosteric inhibitors and activators: a dynamic view through the lens of residue interaction networks. Adv. Exp. Med. Biol. 1163, 187–223 (2019). 3. Simpson, G. L., Hughes, J. A., Washio, Y. & Bertrand, S. M. Direct small-molecule kinase activation: novel approaches for a new era of drug discovery. Curr. Opin. Drug Discov. Dev. 12, 585–596 (2009). 4. Fang, Z., Grutter, C. & Rauh, D. Strategies for the selective regulation of kinases with allosteric modulators: exploiting exclusive structural features. ACS Chem. Biol. 8, 58–70 (2013). 5. Mobitz, H., Jahnke, W. & Cowan-Jacob, S. W. Expanding the opportunities for modulating kinase targets with allosteric approaches. Curr. Top. Med. Chem. 17, 59–70 (2017).
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